University · Statistics · Statistical Inference

Sequential Testing and Group Sequential Designs

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Introduces Wald's sequential probability ratio test, alpha-spending functions, and stopping boundary methods (Pocock, O'Brien-Fleming) used to analyze accumulating data with valid error-rate control, as in clinical trials.

Inhaltsübersicht

  • Foundations: Wald's Sequential Probability Ratio Test
  • Group Sequential Designs and Alpha-Spending Functions
  • Stopping Boundaries: Pocock and O'Brien-Fleming Methods
  • Applications in Clinical Trials and Practical Implementation
Diagram of a sequential probability ratio test showing cumulative likelihood ratio against stopping boundaries
Pixabay – Pixabay License

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